Defender Michael Nottingham produced a great finish 20 minutes from time to earn Accrington a 2-1 triumph at Oxford.
Nottingham controlled a clearance with a fine first touch then hammered in a half-volley from 10 yards to bring Stanley a vital win for their faint hopes of reaching the play-offs, and all but ending Oxford's.
Accrington thought they should have had a goal when Dion Charles looked to have stabbed the ball over the line at a corner, but it was not given.
However, John Coleman's men went in front from their next attack, on 16 minutes, when on-loan QPR forward Paul Smyth fired high into the net from 15 yards.
Oxford equalised nine minutes later with Elliot Lee slotting home from Matt Taylor's pass.
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Jack Stevens' smart double save kept the U's level as he turned Sean McConville's free-kick onto a post then smartly saved a follow-up shot.
At the other end Toby Savin saved well from Lee and Olamide Shodipo before Nottingham popped up with the winner.
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